1 2 Alzheimer ' S Disease , Brain Injury , and C . N . S . Nanotherapy in 3 Humans : Sonoporation Augmenting Drug Targeting
نویسنده
چکیده
ABSTRACT: 10 Owing to the complexity of neurodegenerative diseases, multiple cellular types need to be targeted 11 simultaneously in order for a given therapy to demonstrate any major effectiveness. Ultrasound12 sensitive coated microbubbles (in a targeted nanoemulsion) are available. Versatile small-molecule 13 drug(s) targeting multiple pathways of Alzheimer's disease pathogenesis are known. By 14 incorporating such drug(s) into the targeted LCM/ND lipid nanoemulsion type, one obtains a 15 multitasking combination therapeutic for translational medicine. This multitasking therapeutic 16 targets cell-surface scavenger receptors (mainly SR-BI), making possible for various Alzheimer's17 related cell types to be simultaneously searched out for localized drug treatment in vivo. Besides 18 targeting cell-surface SR-BI, the proposed LCM/ND-nanoemulsion combination therapeutic(s) 19 include a characteristic lipid-coated microbubble [LCM] subpopulation (i.e., a stable LCM 20 suspension); such LCM substantially reduce the acoustic power levels needed for accomplishing 21 temporary noninvasive (transcranial) ultrasound treatment, or sonoporation, if additionally desired 22 for the Alzheimer's patient. 23 24
منابع مشابه
Alzheimer’s Disease, Brain Injury, and C.N.S. Nanotherapy in Humans: Sonoporation Augmenting Drug Targeting
Owing to the complexity of neurodegenerative diseases, multiple cellular types need to be targeted simultaneously in order for a given therapy to demonstrate any major effectiveness. Ultrasound-sensitive coated microbubbles (in a targeted nanoemulsion) are available. Versatile small-molecule drug(s) targeting multiple pathways of Alzheimer’s disease pathogenesis are known. By incorporating such...
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